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ea0077p236 | Reproductive Endocrinology | SFEBES2021

Increased levels of testosterone associated with polycystic ovary syndrome (PCOS) negatively affect HOXA10 and integrin β3 expression in endometrial cells and embryo attachment using a trophoblast cell spheroid model

Reeves Beth , Sidat Raabiah , Harper Claire , Marriott Andrew , Charnock Jayne

PCOS is a reproductive endocrine disorder that affects up to 10% of women of a reproductive age, with 70-80% of patients defined as infertile. There are many different symptoms that could impact fertility in women with PCOS such as anovulation, hyperandrogenism and insulin resistance. A trophoblast (BeWo cell) spheroid attachment assay was used as an in vitro model of embryo implantation to examine the effect of testosterone on the receptivity of endometrial (Ishikawa...

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Increased levels of testosterone associated with polycystic ovary syndrome (PCOS) negatively affect HOXA10 and integrin β3 expression in endometrial cells and embryo attachment using a trophoblast cell spheroid model

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